benzene aplastic anemia
These mainly involve aplastic anaemia the first cases of which were reported in 1897. From 1986 to 1988 a national aplastic anemia incidence survey conducted at 44 survey points municipalities and autonomous regions in 21 provinces of China showed that the incidence rate of aplastic anemia was 07410 million.
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This type of anemia might improve if you avoid repeated exposure to the chemicals that caused your illness.
. Benzene exposures can cause aplastic anemia. Aplastic anemia is not categorized as a cancer but can be just as serious. Exposure to toxic chemicals.
In addition to exposure to benzene all of these conditions have other possible causes and for most people with these conditions the cause is not known. At high levels of benzene exposure air concentration 100 ppm the incidence of aplastic anaemia is approximately 1100 individuals exposed but this drops precipitously at lower levels of exposure 1020 ppm to around 110000. Benzene also impairs hematopoiesis and industrial exposure to benzene figured prominently in the early literature on aplastic anemia.
In order to reduce the harmful effects of this pollutant it is necessary to identify additional preventative measures. Aplastic anemia can lead to other health concerns such as an irregular heartbeat an enlarged heart and heart failure. Exposure to BZ may cause aplastic anemia which is characterized as bone marrow hematopoietic failure.
States in his article titled Benzene as a Leukemogenic and Carcinogenic Agent Amer. Benzene is a colorless and sweet smelling chemical that has been directly related to a portion of the aplastic anemia cases. Benzene BZ is an important occupational and environmental pollutant.
Inhalation of high concentrations can affect central nervous system function. This disease can lead to damaged bone marrow. Aplastic anemia can also lead to leukemia or myelodysplasia.
Benzene now is a negligible risk factor accounting for only a small etiologic fraction in most countries 1 2. Severe chronic benzene poisoning at doses 100 ppm is an established cause of aplastic anemia and leukemia. These mainly involve aplastic anaemia the first cases of which were reported in 1897.
At high levels of benzene exposure air concentration 100 ppm the incidence of aplastic anaemia is approximately 1100 individuals exposed but this drops precipitously at lower levels of exposure 1020 ppm to around 110000. Benzene an inexpensive solvent also damages hematopoiesis and industrially exposed workers figured prominent in the early literature of aplastic anemia. Benzene used as a solvent in many industries is a known carcinogen which can lead to variety of hematological manifestations like macrocytic anemia aplastic anemia myelodysplasticsyndrome and leukemia.
This chemical is naturally found in the environment as well as in many man-made products such as industrial solvents drugs plastics gasoline dyes synthetic rubber resins detergents and lubricants. These mainly involve aplastic anaemia the first cases of which were reported in 1897. Aplastic anemia can be a temporary side effect of these treatments.
Aplastic anemia caused by bone marrow suppression is the classic cause of death in chronic benzene poisoning. 1 The annual incidence of aplastic anemia in the United Kingdom was only 0210 million whereas the rate in Asia was 2- to 3-fold higher. Fatal aplastic anemia following benzene exposure was first reported in workers in the 19th century.
The association between benzene exposure and bone marrow suppression has been recognized since 1897. There are different types of aplastic anemia including Fanconi anemia. Systemic absorption may cause depression of the hematopoietic system pancytopenia aplastic anemia and leukemia.
Overview of benzene-induced aplastic anaemia The scientific literature is replete with reports of cases of benzene-induced toxicity to the haematopoietic system. Some studies even reported the use of benzene in the treatment of leukemia for its ability to reduce bone marrow activity. Exposure to BZ may cause aplastic anemia which is characterized as bone marrow hematopoietic failure.
At high level of benzene exposure air concentration 100 ppm the incidence of aplastic. It can be caused by injury to blood stem cells due to exposure to certain drugs chemotherapy congenital disorders drug therapy to suppress the immune system pregnancy radiation therapy or toxins such as benzene or arsenic. Toxic substances such as pesticides arsenic and benzene Radiation therapy and chemotherapy for cancer Certain medicines Infections such as hepatitis Epstein-Barr virus or HIV Autoimmune disorders Certain inherited conditions Pregnancy.
Benzene appeared to be effective especially if used after x-ray therapy 1. Aplastic anemia is also sometimes associated with exposure to toxins such as benzene or with the use of certain drugs including chloramphenicol carbamazepine felbamate phenytoin quinine and phenylbutazone. However benzene induced aplastic anemia in diamond industry has not been reported so far in literature.
In fact several cases of aplastic anemia and aplastic bone marrow were described in workers exposed to benzene. Aplastic anemia is a rare condition that occurs when your body stops producing enough new blood cells. Benzene BZ is an important occupational and environmental pollutant.
The precise mechanism of action of benzene and benzene-metabolite toxicity in humans is not fully understood mainly for two reasons 1 the low natural incidence of aplastic anemia and 2 the first contact with the patient generally occurs in advanced stages. Occupational studies have established that benzene can cause aplastic anemia. 89-20 1985 Although the use of benzene started around the second half of 19th century the chronic toxic effect of this chemical agent was.
Toxic chemicals such as some used in pesticides and insecticides and benzene an ingredient in gasoline have been linked to aplastic anemia. According to the Agency for Toxic Substances Disease Registry a division of the Department of Health Human Services Benzene-induced aplastic anemia is caused by chronic exposure at relatively high doses Fatal aplastic anemia following benzene exposure was first reported in workers in the 19th century. Benzene exposure is now a.
Benzene can also cause acute myeloid leukemia AML and might cause other types of leukemia as well. Benzene is primarily an inhalation hazard. However the probability that these drugs will lead to aplastic anemia in a given patient is very low.
In order to reduce the harmful effects of this pollutant it is necessary to identify additional preventative measures.
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